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Search Results for " neurotoxin ii "

Targets Recommended: Sodium Channel Parasite

4

抑制剂 & 化合物

2

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T27794	λ-Cyhalothrin lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon	Sodium Channel; Parasite	Membrane transporter/Ion channel; Microbiology/Virology
	λ-Cyhalothrin (Icon) 是广谱的 II 型合成除虫菊酯杀虫剂，含有 α-氰基，用于防治多种害虫。它是一种钠通道神经毒素，靶向中枢神经系统中神经元膜。
T33346	Methylaminoalanine-nickel(II) L-Bmma-nickel(II),L-Medap-nickel(II)
	Methylaminoalanine-nickel(II) can be regarded as a naturally occurring neurotoxin.
T80427	Jingzhaotoxin-II	Sodium Channel	Membrane transporter/Ion channel
	Jingzhaotoxin-II是由32个氨基酸组成的神经毒素，包括两个酸性残基和两个碱性残基。该毒素能够抑制电压门控钠通道(VGSC)，并在心肌细胞上明显减缓TTX抗性(TTX-R) VGSC的快速失活，其IC50值为0.26μM。
TP2016	Huwentoxin-IV Huwentoxin IV
	Selective NaV1.7 channel blocker. Preferentially inhibits neuronal NaV1.7, 1.2 and 1.3 (IC50 values are 26, 150 and 338 nM respectively), compared to muscle subtypes NaV1.4 and 1.5 (IC50 = >10 μM). Inhibits the channel by binding at the neurotoxin recepto

化合物

Cat.No: T27794

Synonym: lambda-Cyhalothrin,Karate,λ-氯氟氰菊酯,Icon

Target: Sodium Channel, Parasite

Methylaminoalanine-nickel(II)

Cat.No: T33346

Synonym: L-Bmma-nickel(II),L-Medap-nickel(II)

Jingzhaotoxin-II

Cat.No: T80427

Target: Sodium Channel

Cat.No: TP2016

Synonym: Huwentoxin IV

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-00054	AaH II Protein, Androctonus australis, Recombinant (His & SUMO) Toxin II,Neurotoxin II,AaHII<...	Androctonus australis	E. coli
	AaH II Protein, Androctonus australis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.3 kDa and the accession number is P01484.
TMPH-00056	Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His) ATX II,Delta-AITX-Avd1c,Toxin II,Delta-act...	Anemonia sulcata	P. pastoris (Yeast)
	Binds specifically to voltage-gated sodium channels (Nav) (site 3), thereby delaying their inactivation. Has a strong effect on crustaceans and insects (DmNav1) and a weaker effect on mammals. This toxin is highly potent at mammalian Nav1.1/SCN1A (EC(50)=6.01 nM) and Nav1.2/SCN2A (EC(50)=7.88 nM). It has also great activity on Nav1.5/SCN5A (EC(50)=49.05 nM), Nav1.4/SCN4A (EC(50)=109.49 nM) and Nav1.6/SCN8A (EC(50)=about 180 nM) and is less potent on Nav1.3/SCN3A (EC(50)=759.22 nM) (when measured...

重组蛋白

AaH II Protein, Androctonus australis, Recombinant (His & SUMO)

Cat.No: TMPH-00054

Species: Androctonus australis

Expression System: E. coli

Delta-AITX-Avd1c Protein, Anemonia sulcata, Recombinant (His)

Cat.No: TMPH-00056

Species: Anemonia sulcata

Expression System: P. pastoris (Yeast)

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